Fzo/mitofusin HR2 domain (IPR006884)

Short name: Fzo/mitofusin_HR2

Overlapping homologous superfamilies


Domain relationships



This entry represents the heptad repeat domain which is conserved at the C terminus of Fzo/mitofusion family of GTPases. Fzo is a mediator of mitochondrial fusion during spermatogenesis [PMID: 9230308]. This conserved region is also found in the human mitofusin protein [PMID: 11181170].

This domain forms a dimeric antiparallel coiled coil structure, which has been proposed to act as a mitochodrial tether before vesicle fusion [PMID: 15297672].

GO terms

Biological Process

GO:0008053 mitochondrial fusion

Molecular Function

GO:0003924 GTPase activity

Cellular Component

GO:0016021 integral component of membrane
GO:0005741 mitochondrial outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.