Elongator complex protein 1 (IPR006849)

Short name: Elp1

Family relationships



Elongator complex protein 1 (also known as Iki3) is a component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme. The eukaryotic elongator complex has been associated with many cellular activities, including transcriptional elongation [PMID: 10024884, PMID: 11689709], but its main function is tRNA modification [PMID: 15769872, PMID: 23165209]. It is required for the formation of 5-methoxy-carbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups on uridine nucleosides present at the wobble position of many tRNAs [PMID: 22889844].

GO terms

Biological Process

GO:0002098 tRNA wobble uridine modification

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0033588 Elongator holoenzyme complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.