Domain

Association with the SNF1 complex (ASC) domain (IPR006828)

Short name: ASC_dom

Domain relationships

None.

Description

Association with the SNF1 complex (ASC) domain is found in the Sip1/Sip2/Gal83/AMPKbeta subunits of the SNF1/AMP-activated protein kinase (AMPK) complex [PMID: 11252725]. The SNF1/AMPK are heterotrimeric enzymes composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit [PMID: 9121458]. Saccharomyces cerevisiae encodes three beta-subunit genes, Sip1, Sip2 and Gal83 [PMID: 7813428, PMID: 10990457]. The beta-subunits function as target selective adaptors that recruit the catalytic kinase and regulator Snf4/gamma-subunits. The ASC domain is required for interaction with Snf4 [PMID: 11252725, PMID: 9121458].

The SNF1 kinase complex is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation [PMID: 17981722, PMID: 10207618]. As glucose levels decrease, Snf1 is activated and promotes the use of alternative carbon sources.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam