Domain

Intermediate filament head, DNA-binding domain (IPR006821)

Short name: Intermed_filament_DNA-bd

Domain relationships

None.

Description

This entry represents the N-terminal head domain of intermediate filaments. Intermediate filament heads bind DNA [PMID: 11513613]. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis [PMID: 11160829]. Phosphorylation of the head region can affect filament stability [PMID: 12177195]. The head has been shown to interaction with the rod domain of the same protein [PMID: 12064937].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005882 intermediate filament

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam