Domain

Caudal-like activation domain (IPR006820)

Short name: Caudal_activation_dom

Domain relationships

None.

Description

This domain occurs at the N-terminal of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 (P43241) is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway [PMID: 11729123]. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (IPR001356).

GO terms

Biological Process

GO:0007275 multicellular organism development
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam