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Overview
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Structures
Glycosyl transferase, family 17 (IPR006813)
Short name: Glyco_trans_17
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumour progression [PMID: 11986323, PMID: 11784313].
GO terms
Biological Process
GO:0006487 protein N-linked glycosylation
Molecular Function
GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
Cellular Component
GO:0016020 membrane