RNA polymerase II subunit A (IPR006811)

Short name: RNA_pol_II_suA

Overlapping homologous superfamilies


Family relationships



The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB [PMID: 12660165]. It binds to TFIIB and is also involved in mRNA elongation. Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation. Ssu72 is also essential for transcription termination of snRNAs [PMID: 12453421].

GO terms

Biological Process

GO:0006397 mRNA processing

Molecular Function

GO:0004721 phosphoprotein phosphatase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.