Apolipoprotein A-II (ApoA-II) (IPR006801)

Short name: ApoA-II

Overlapping homologous superfamilies

Family relationships



Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge [PMID: 12119188]. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear [PMID: 12119188]. In bovine serum, the ApoA-II homologue is present in almost free form. Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS) [PMID: 9538260].

GO terms

Biological Process

GO:0006869 lipid transport
GO:0042157 lipoprotein metabolic process

Molecular Function

GO:0008289 lipid binding

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.