Domain

Pinin/SDK (IPR006787)

Short name: Pinin_SDK_N

Domain relationships

None.

Description

This conserved region is found at the N-terminal of the member proteins. It is located adjacent and N-terminal to the pinin/SKD/memA domain IPR006786. Members of this family have very varied localisations within the eukaryotic cell. Pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque [PMID: 8922384, PMID: 9447706]. SDK2/3 is a dynamically localised nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing [PMID: 12051732]. MemA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions [PMID: 10645008].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
ProDom