Poxvirus I3 ssDNA-binding (IPR006754)

Short name: Poxvirus_I3_ssDNA-bd

Overlapping homologous superfamilies


Family relationships



The 34kDa protein encoded by the I3 gene of vaccinia virus is expressed at early and intermediate times post-infection and is phosphorylated on serine residues. I3 protein demonstrates a striking affinity for single-stranded, but not for double-stranded, DNA which suggests a role in DNA replication and/or repair. Electrophoretic mobility shift assays indicate that numerous I3 molecules can bind to a template, reflecting the stoichiometric interaction of I3 with DNA. Sequence analysis reveals that a pattern of aromatic and charged amino acids common to many replicative single-stranded DNA binding proteins (SSBs) is conserved in I3 [PMID: 9525612].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003697 single-stranded DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.