Aminoglycoside/hydroxyurea antibiotic resistance kinase (IPR006748)

Short name: NH2Glyco/OHUrea_AB-resist_kin

Overlapping homologous superfamilies

Family relationships



The aminoglycosides are a large group of biologically active bacterial secondary metabolites, best known for their antibiotic properties [PMID: 9211644]. Aminoglycoside phosphotransferases achieve inactivation of these enzymes by phosphorylation, utilising ATP. Likewise, hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety.

GO terms

Biological Process

GO:0006468 protein phosphorylation
GO:0019748 secondary metabolic process

Molecular Function

GO:0016773 phosphotransferase activity, alcohol group as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.