Motilin/ghrelin-associated peptide (IPR006737)

Short name: Motilin_assoc

Overlapping homologous superfamilies


Domain relationships



Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas [PMID: 9210180].

This domain is also found in ghrelin, a growth hormone secretagogue synthesised by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system [PMID: 11306336].

This domain represents a peptide sequence that lies C-terminal to motilin/ghrelin (IPR006738) on the respective precursor peptide. Its function is unknown.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005179 hormone activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.