Family

Leukocyte surface antigen CD47 (IPR006704)

Short name: CD47

Family relationships

None.

Description

Leukocyte surface antigen CD47 (also known as integrin-associated protein, IAP) is a widely expressed membrane protein with multiple functions in immunological and neuronal processes. For example, CD47-induces caspase-independent cell death which may be mediated by cytoskeleton reorganisation [PMID: 12351399]. In red blood cells, CD47 acts like a marker of self by ligating the macrophage inhibitory receptor signal regulatory protein alpha [PMID: 11986200]. The protein can also act as a thrombospondin receptor [PMID: 11980922].

This pattern also recognises a group of CD-47-like proteins found in poxviruses (Poxviridae).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER