Domain

Thioesterase domain (IPR006683)

Short name: Thioestr_dom

Domain relationships

Description

A wide variety of enzymes contain this domain, principally thioesterases. Proteins containing this domain include 4HBT (4-hydroxybenzoyl-CoA thioesterase) (EC:3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3 [PMID: 9837940, PMID: 1610806]. It also includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters [PMID: 8805534].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam