Domain

Amidohydrolase 1 (IPR006680)

Short name: Amidohydro_1

Domain relationships

None.

Description

Proteins containing this domain are enzymes from a large metal dependent hydrolase superfamily [PMID: 9144792]. The family includes adenine deaminase (EC:3.5.4.2) that hydrolyses adenine to form hypoxanthine and ammonia. This reaction is important for adenine utilisation as a purine and also as a nitrogen source [PMID: 8550522]. The family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases (EC:3.5.1.25). The domain is also found in the urease alpha subunit, where it is the catalytic domain [PMID: 7754395].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam