tRNA-splicing endonuclease (IPR006676)

Short name: tRNA_splic

Overlapping homologous superfamilies


Family relationships


tRNA-splicing endonucleases (EC: catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini [PMID: 9321408, PMID: 9200603]. The genes encoding these proteins are homologous in eukaryotes and archea. The eukaryotic tRNA-splicing endonucleases are heterotetrameric while the archaeal endonucleases can be split into homodimeric and homotetrameric subgroups.

GO terms

Biological Process

GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation

Molecular Function

GO:0000213 tRNA-intron endonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.