SLC41 divalent cation transporters, integral membrane domain (IPR006667)

Short name: SLC41_membr_dom

Overlapping homologous superfamilies

Domain relationships



The SLC41 family of divalent cation transporters includes MgtE (SLC41A1), SLC41A2 and SLC41A3. The prokaryote orthologue, MgtE, is a magnesium transporter [PMID: 17700703]. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ [PMID: 15809054].

This entry represents the integral membrane region of SLC41 transporter proteins. Bacterial family members have one copy of this region while archaeal and eukaryotic sequences have two. This suggests that the bacterial proteins may act as dimers.

GO terms

Biological Process

GO:0006812 cation transport

Molecular Function

GO:0008324 cation transmembrane transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.