Domain

Outer membrane protein, OmpA/MotB, C-terminal (IPR006665)

Short name: OmpA/MotB_C

Domain relationships

Description

This entry represents domain with a beta/alpha/beta/alpha-beta(2) structure found in the C-terminal region of many Gram-negative bacterial outer membrane proteins [PMID: 1538702], such as porin-like integral membrane proteins (such as ompA) [PMID: 2202726], small lipid-anchored proteins (such as pal) [PMID: 10515919], and MotB proton channels [PMID: 17052729]. The N-terminal half is variable although some of the proteins in this group have the OmpA-like transmembrane domain IPR000498 at the N terminus. OmpA from Escherichia coli is required for pathogenesis, and can interact with host receptor molecules [PMID: 17368067]. MotB (and MotA) serves two functions in E. coli, the MotA(4)-MotB(2) complex attaches to the cell wall via MotB to form the stator of the flagellar motor, and the MotA-MotB complex couples the flow of ions across the cell membrane to movement of the rotor [PMID: 17052729].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles
GENE3D
SUPERFAMILY