Prolyl 4-hydroxylase, alpha subunit (IPR006620)
Short name: Pro_4_hyd_alph
- Oxoglutarate/iron-dependent dioxygenase (IPR005123)
- Prolyl 4-hydroxylase, alpha subunit (IPR006620)
Mammalian prolyl 4-hydroxylase alpha catalyses the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly-sequences in collagens and other proteins. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor [PMID: 11276424].
GO:0055114 oxidation-reduction process
No terms assigned in this category.
- SM00702 (P4Hc)