Prolyl 4-hydroxylase, alpha subunit (IPR006620)

Short name: Pro_4_hyd_alph

Overlapping homologous superfamilies


Domain relationships


Mammalian prolyl 4-hydroxylase alpha catalyses the posttranslational formation of 4- hydroxyproline in -xaa-pro-gly-sequences in collagens and other proteins. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor [PMID: 11276424].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0031418 L-ascorbic acid binding
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.