Repeat

PQ-loop repeat (IPR006603)

Short name: PQ-loop_rpt

Description

Some membrane bound proteins possess a pair of repeats each spanning two transmembrane helices connected by a loop [PMID: 11731489]. The PQ motif found on loop 2 is critical for the localisation of cystinosin to lysosomes [PMID: 11150305]. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought to possess a more general function; most probably this involves a glutamine residue [PMID: 11731489].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART