Family

Lipopolysaccharide-modifying protein (IPR006598)

Short name: LipoPS_modifying

Family relationships

None.

Description

The CAP10 domain is found in glycosyltransferases found in animals, plants and fungi. In animals, glucosyltransferases catalyze the transfer of glucose and/or xylose from UDP-glucose and UDP-xylose, respectively, to a serine within the consensus Cys-Xaa-Ser-Xaa-Pro-Cys) in epidermal growth factor repeats, such as those found in coagulation factors F7, F9 and NOTCH proteins. Notch signaling is regulated by Notch glucosylation and glucosylation is required for the correct folding and cleavage of Notch [PMID: 18243100, PMID: 21490058].

The pathogenic fungus Cryptococcus neoformans, which most commonly affects the central nervous system and causes fatal meningoencephalitis primarily in patients with AIDS, produces a thick extracellular polysaccharide capsule which is well recognised as a virulence factor. The CAP10 domain is required for capsule formation and virulence [PMID: 10482503]. The capsule is primarily made of two xylose-containing polysaccharides, glucuronoxylomannan and galactoxylomannan, and the glycosyltransferase transfers xylose to alpha-1,3-dimannoside in a beta-1,2-linkage [PMID: 17430900].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam