Domain

Peptide N glycanase, PAW domain (IPR006588)

Short name: Peptide_N_glycanase_PAW_dom

Domain relationships

None.

Description

The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C terminus of metazoan peptide:N-glycanase (PNGase) and in multiple copies in hypothetical Caenorhabditis elegans proteins peptide:N-glycanases (PNGases) [PMID: 11779830]. The C-terminal PAW domain of PNGase binds to the mannose moieties of N-linked oligosaccharide chains [PMID: 17088551].

The PAW domain is a slightly elongated molecule and displays a beta-sandwich architecture, which is composed of two layers, containing nine and eight antiparallel beta-strands, respectively, and three additional short helices [PMID: 17088551].

Some proteins known to contain a PAW domain are listed below:

  • Animal peptide:N-glycanase (PNGase) EC:3.5.1.52, catalyses the deglycosylation of several misfolded N-linked glycoproteins by cleaving the bulky glycan chain before the proteins are degraded by the proteasome.
  • Caenorhabditis elegans putative uncharacterised protein C17B7.5.

GO terms

Biological Process

GO:0006516 glycoprotein catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART
PROSITE profiles