ATP-dependent helicase, C-terminal (IPR006555)

Short name: ATP-dep_Helicase_C

Overlapping homologous superfamilies

Domain relationships



This domain of unknown function is found at the C terminus of some ATP-dependent helicases characterised by a 'D-E-A-H' motif. This resembles the 'D-E-A-D-box' of other known helicases, a special version of the B motif of ATP-binding proteins however His replaces the second Asp. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre-mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

GO terms

Biological Process

GO:0006139 nucleobase-containing compound metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0003676 nucleic acid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.