HAD-superfamily hydrolase,subfamily IIIA (IPR006549)

Short name: HAD-SF_hydro_IIIA

Overlapping homologous superfamilies

Domain relationships


This group of proteins is a part of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The Class III subfamilies are characterised by the lack of any domains located either between the first and second conserved catalytic motifs (as in the Class I subfamilies) or between the second and third conserved catalytic motifs (as in the Class II subfamilies) of the superfamily domain [PMID: 7966317, PMID: 11601995]. The IIIA subfamily contains five major clades: histidinol-phosphatase [PMID: 3007936], histidinol-phosphatase-related protein, DNA 3-phosphatase and sequences related to YqeG and YrbI.

In the case of histidinol phosphatase and PNK-3'-phosphatase, this entry represents a domain of a bifunctional system. In the histidinol phosphatase HisB, a C-terminal domain is an imidazoleglycerol-phosphate dehydratase which catalyses a related step in histidine biosynthesis [PMID: 3007936]. In PNK-3'-phosphatase, N- and C-terminal domains constitute the polynucleotide kinase and DNA-binding components of the enzyme.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.