P-type ATPase, subfamily IV (IPR006539)

Short name: P-type_ATPase_IV

Overlapping homologous superfamilies

Family relationships


P-ATPases (also known as E1-E2 ATPases) (EC:3.6.3.-) are found in bacteria and in a number of eukaryotic plasma membranes and organelles [PMID: 9419228]. P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases, which transport specific types of ion: H+, Na+, K+, Mg2+, Ca2+, Ag+ and Ag2+, Zn2+, Co2+, Pb2+, Ni2+, Cd2+, Cu+ and Cu2+. P-ATPases can be composed of one or two polypeptides, and can usually assume two main conformations called E1 and E2.

Type IV ATPases have been shown to be involved in the transport of phospholipids [PMID: 9419228]. These ATPases are found only in eukaryotes.

GO terms

Biological Process

GO:0015914 phospholipid transport

Molecular Function

GO:0005524 ATP binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.