Bacteriophage holin (IPR006485)

Short name: Phage_holin

Family relationships



Phage proteins for bacterial lysis typically include a membrane-disrupting protein, or holin, and one or more cell wall degrading enzymes that reach the cell wall because of holin action. Holins are found in a large number of mutually non-homologous families.

This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis [PMID: 11459934].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.