D-erythrose-4-phosphate dehydrogenase (IPR006422)

Short name: E4P_DH_bac

Overlapping homologous superfamilies

Family relationships


This entry contains a small clade of dehydrogenases in gamma-proteobacteria which utilise NAD+ to oxidize erythrose-4-phosphate (E4P) to 4-phospho-erythronate, a precursor for the de novo synthesis of pyridoxine via 4-hydroxythreonine and D-1-deoxyxylulose [PMID: 7751290]. This enzyme activity appears to have evolved from glyceraldehyde-3-phosphate dehydrogenase, whose substrate differs only in the lack of one carbon relative to E4P. It is possible that some of the GAPDH enzymes may prove to be bifunctional in certain species.

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0042823 pyridoxal phosphate biosynthetic process

Molecular Function

GO:0051287 NAD binding
GO:0048001 erythrose-4-phosphate dehydrogenase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.