Methylaspartate ammonia-lyase (IPR006395)

Short name: Me_Asp_am_lyase

Overlapping homologous superfamilies

Family relationships


Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the main catabolic pathway for glutamate. MAL belongs to the enolase superfamily of enzymes, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion [PMID: 11748244, PMID: 11796115, PMID: 9385136].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0050096 methylaspartate ammonia-lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.