Family

Glutamate mutase sigma subunit (IPR006394)

Short name: GlmS

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry represents the sigma subunit (GlmS) of glutamate mutase, a cobalamin-dependent enzyme that catalyses the first step in a pathway of glutamate fermentation [PMID: 12413543]. It catalyses the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate) [PMID: 7880251]. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'-desoxyadenosyl radical, which is generated by the homolytic cleavage of the organometallic bond of the cofactor B12. The enzyme consists of an heterotetramer of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS) [PMID: 10915555, PMID: 9739092].

GO terms

Biological Process

GO:0019670 anaerobic glutamate catabolic process

Molecular Function

GO:0016866 intramolecular transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
HAMAP
CDD