4-hydroxybenzoate polyprenyltransferase (IPR006370)

Short name: HB_polyprenyltransferase

Overlapping homologous superfamilies


Family relationships


Members of this family show a broad specificity for prenyl diphosphates, accepting substrates of different chain lengths. Genes coding for these enzymes have been identified in many organisms, and are mostly responsible for ubiquinone (UQ) biosynthesis [PMID: 15604701, PMID: 16501255, PMID: 15153069]. 4-hydroxybenzoate solanesyltransferase from cyanobacteria displays a broad specificity with regard to the prenyl donor substrate and uses not only solanesyl diphosphate, but also a number of shorter-chain prenyl diphosphates [PMID: 22166075]. One exception is LePGT1 (Lithospermum erythrorhizon 4-hydroxybenzoic acid geranyltransferase), which only accepts GPP (geranyl diphosphate) and is involved in the biosynthesis of a red naphthoquinone, shikonin, a plant secondary metabolite [PMID: 19392660]. LePGT1 was reported to be the key regulatory enzyme of shikonin biosynthesis [PMID: 2774555] and is not relevant to the formation of UQ [PMID: 11744717].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004659 prenyltransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.