4-hydroxybenzoate polyprenyl transferase (IPR006370)

Short name: HB_polyprenyl-transferase

Family relationships


These sequences are a family of integral membrane proteins that condense para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in Escherichia coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterised members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterised members IPR006371 [PMID: 11092853].

GO terms

Biological Process

GO:0009058 biosynthetic process
GO:0006744 ubiquinone biosynthetic process

Molecular Function

GO:0004659 prenyltransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.