Protohaem IX farnesyltransferase (IPR006369)

Short name: Protohaem_IX_farnesylTrfase

Family relationships


This entry represents protoheme IX farnesyltransferase, also known as haem O synthase, an enzyme that creates an intermediate in the biosynthesis of haem A [PMID: 9378722]. This enzyme converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor.

GO terms

Biological Process

GO:0048034 heme O biosynthetic process

Molecular Function

GO:0008495 protoheme IX farnesyltransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.