HAD hydrolase, LHPP/HDHD2 (IPR006355)

Short name: LHPP/HDHD2

Overlapping homologous superfamilies

Family relationships


Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) hydrolyzes nitrogen-phosphorus bonds in phospholysine, phosphohistidine and imidodiphosphate as well as oxygen-phosphorus bonds in inorganic pyrophosphate in vitro [PMID: 12801912]. This family also includes human haloacid dehalogenase like hydrolase domain containing 2 protine (HDHD2) a phosphatase which may be involved in polygenic hypertension [PMID: 26103128]. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.