Adenosine/adenine deaminase (IPR006330)

Short name: Ado/ade_deaminase

Overlapping homologous superfamilies

Family relationships


Adenosine deaminases are monomeric zinc dependent enzymes involved in purine metabolism. They are required for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Adenosine deaminases convert adenosine to the related nucleoside inosine by the substitution of the amino group for a hydroxyl group. These enzymes are distantly related to AMP deaminases [PMID: 1998686].

This entry also includes a group of adenine deaminases more related to the bacterial and eukaryotic adenosine deaminases than to Bacillus subtilis adenine deaminase and its bacterial homologues [PMID: 14643670]. Adenine deaminase catalyses the hydrolytic deamination of adenine to hypoxanthine.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019239 deaminase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.