AMP deaminase (IPR006329)

Short name: AMPD

Overlapping homologous superfamilies

Family relationships


AMP-deaminase (AMPD) is a large, well-conserved eukaryotic protein that catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) to inosine monophosphate (IMP), and so plays an important role in purine metabolism. In mammalian liver, the reaction catalysed by AMP-deaminase constitutes a rate-limiting step in adenine nucleotide catabolism [PMID: 18493842].

Not all members of the family are active enzymes: YBR284W and YJL070C lack residues for binding the catalytic zinc ion, and YJL070C lacks substrate binding residues.

GO terms

Biological Process

GO:0032264 IMP salvage

Molecular Function

GO:0003876 AMP deaminase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.