Transcription elongation factor, TFIIS (IPR006289)

Short name: TFSII

Overlapping homologous superfamilies

Family relationships


Transcription elongation factor IIS (TFIIS) is a component of RNA polymerase II preinitiation complexes, and is required for preinitiation complex assembly and stability [PMID: 17913884]. The association of TFIIS with a promoter depends on functional preinitiation complex components including Mediator and the SAGA complex [PMID: 17901206]. TFIIS is composed of three domains: domain 1 forms a 4-helical bundle that appears to bind certain initiation factors; domain 2 forms a 3-helical bundle and is required for Pol II binding; domain 3 forms a zinc ribbon and is essential for stimulation of RNA cleavage [PMID: 16648364, PMID: 10940308].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0006351 transcription, DNA-templated

Molecular Function

GO:0003676 nucleic acid binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.