Protein DJ-1 (IPR006287)

Short name: DJ1

Family relationships



Glycation is a nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein inactivation. DJ-1 was described in vitro as a protein deglycase that repaired methylglyoxal- and glyoxal-glycated proteins [PMID: 25416785, PMID: 26995087]. Since then there have been reports against [PMID: 27903648], and supporting this role for DJ-1 [PMID: 28013050]. DJ-1/Park7 has been associated with human parkinsonism [PMID: 12446870]. Included in this family is also YajL from Escherichia coli, the bacterial homologue of DJ-1 [PMID: 20889753, PMID: 26774339].

This group of proteins are classified as either DJ-1 putative peptidases or non-peptidase homologues in MEROPS peptidase family C56 (clan PC(C)).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.