Family

Thiamine-monophosphate kinase (IPR006283)

Short name: ThiL

Overlapping homologous superfamilies

Family relationships

Description

This family represents thiamine-monophosphate kinase (ThiL), an enzyme that converts thiamine monophosphate into thiamine pyrophosphate (TPP, coenzyme B1), an enzyme cofactor [PMID: 18311927, PMID: 9188462, PMID: 4567662, PMID: 6284709]. Thiamine monophosphate may be derived from de novo synthesis or from unphosphorylated thiamine, known as vitamin B1. The N-terminal domain of ThiL binds ATP and is related to the ATP-binding domains of hydrogen expression/formation protein HypE, the AIR synthases, FGAM synthase and selenophosphate synthetase (SelD). Eukaryotes lack this enzyme, and add pyrophosphate from ATP to unphosphorylated thiamine in a single step.

GO terms

Biological Process

GO:0009228 thiamine biosynthetic process

Molecular Function

GO:0009030 thiamine-phosphate kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
HAMAP
PANTHER
TIGRFAMs
PIRSF