Orotate phosphoribosyltransferase, bacterial (IPR006273)

Short name: Orotate_PRibTrfase_bac

Overlapping homologous superfamilies

Family relationships


This group of sequences are a distinct clade of bacterial orotate phosphoribosyltransferases. Members include the experimentally determined example from Thermus aquaticus and additional examples from Caulobacter crescentus, Helicobacter pylori (Campylobacter pylori), Rhizobium loti (Mesorhizobium loti), and related species.

Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. In the pyrimidine synthesis pathway, OPRT catalyses the reversible phosphoribosyl transfer from 5'-phospho-alpha-D-ribose 1'-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5'-monophosphate (OMP) [PMID: 22075667]. The structures and properties of the OPRTases from different species have been described in several publications [PMID: 12872993, PMID: 9305779, PMID: 8720144, PMID: 8487307].

GO terms

Biological Process

GO:0019856 pyrimidine nucleobase biosynthetic process

Molecular Function

GO:0004588 orotate phosphoribosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.