Family

3-deoxy-8-phosphooctulonate synthase (IPR006269)

Short name: KDO8P_synthase

Overlapping homologous superfamilies

Family relationships

None.

Description

These sequences describe 2-dehydro-3-deoxyphosphooctonate aldolase. Alternate names include 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate.

phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate

In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide.

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0008676 3-deoxy-8-phosphooctulonate synthase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
HAMAP
PANTHER