Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (IPR006257)

Short name: LAT1

Overlapping homologous superfamilies

Family relationships



The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) [PMID: 1825611]. This entry represent the dihydrolipoamide acetyltransferase (E2) subunit (EC:, also known as Lat1.

GO terms

Biological Process

GO:0006090 pyruvate metabolic process

Molecular Function

GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity

Cellular Component

GO:0045254 pyruvate dehydrogenase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.