Isocitrate lyase (IPR006254)

Short name: Isocitrate_lyase

Overlapping homologous superfamilies

Family relationships



Isocitrate lyase (EC: [PMID: 2696959, PMID: 2361956] is an enzyme that catalyzes the conversion of isocitrate to succinate and glyoxylate. This is the first step in the glyoxylate bypass, an alternative to the tricarboxylic acid cycle (also known as the TCA cycle) in bacteria, fungi and plants. A cysteine, a histidine and a glutamate or aspartate have been found to be important for the enzyme's catalytic activity. Only one cysteine residue is conserved between the sequences of the fungal, plant and bacterial enzymes; it is located in the middle of a conserved hexapeptide.

GO terms

Biological Process

GO:0019752 carboxylic acid metabolic process

Molecular Function

GO:0004451 isocitrate lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.