Malate synthase A (IPR006252)

Short name: Malate_synthA

Overlapping homologous superfamilies

Family relationships


This entry represents glyoxysomal malate synthases and one of two bacterial forms, designated malate synthase A.

Malate synthase and isocitrate lyase are the two characteristic enzymes of the glyoxylate cycle. The glyoxylate cycle allows certain organisms, like plants and fungi, to derive their carbon requirements from two-carbon compounds, by bypassing the two carboxylation steps of the citric acid cycle [PMID: 11252898]. Isocitrate lyase, first catalyzes the aldol cleavage of isocitrate to succinate (an intermediate of the tricarboxylic acid cycle) and glyoxylate. Then malate synthase catalyzes the condensation of acetyl CoA with glyoxylate to yield malate (another intermediate of the tricarboxylic acid cycle) [PMID: 9891796].

GO terms

Biological Process

GO:0006097 glyoxylate cycle

Molecular Function

GO:0004474 malate synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.