Malate:quinone-oxidoreductase (IPR006231)

Short name: MQO

Family relationships



The membrane-associated enzyme, malate:quinone-oxidoreductase, is an alternative to the better-known NAD-dependent malate dehydrogenase as part of the TCA cycle. The reduction of a quinone rather than NAD+ makes the reaction essentially irreversible in the direction of malate oxidation to oxaloacetate. Both forms of malate dehydrogenase are active in Escherichia coli; disruption of this form causes less phenotypic change. In some bacteria, this form is the only or the more important malate dehydrogenase [PMID: 11092847].

GO terms

Biological Process

GO:0006099 tricarboxylic acid cycle

Molecular Function

GO:0008924 malate dehydrogenase (quinone) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.