Domain

Polycystin cation channel (IPR006228)

Short name: Polycystin_cat

Domain relationships

None.

Description

This represents the N-terminal region of polycystin, a member of the Polycystin Cation Channel (PCC) family. Polycystin is a huge protein of 4303aa. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative transmembrane regions in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects [PMID: 9889186, PMID: 10517637].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs