Glycine cleavage system T protein (IPR006223)

Short name: GCS_T

Overlapping homologous superfamilies

Family relationships


The glycine cleavage system (GCS) is a multienzyme system composed of proteins P, H, T, and L, that catalyses the reversible oxidation of glycine. The T protein is an aminomethyl transferase EC: that catalyses the following reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein

The glycine cleavage system is found in bacteria and the mitochondria of eukaryotes. Mutations in the human T-protein gene are known to cause nonketotic hyperglycinemia [PMID: 20375021].

GO terms

Biological Process

GO:0006546 glycine catabolic process

Molecular Function

GO:0004047 aminomethyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.