Aminomethyltransferase, folate-binding domain (IPR006222)

Short name: GCV_T_N

Overlapping homologous superfamilies

Domain relationships



This domain is found at the N terminus of glycine cleavage T-proteins, which are part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein (aminomethyltransferase, EC: is a folate-dependent enzyme that catalyses the release of ammonia and the transfer of the methylene carbon unit (C1 unit) to tetrahydrofolate (H4folate) from the aminomethyl intermediate attached to the lipoate cofactor of H-protein [PMID: 9047339, PMID: 16051266].

This domain is also found in YgfZ proteins. YgfZ in E.coli is a folate binding protein involved in RNA modification and regulation of chromosomal replication initiation [PMID: 16359333]. YgfZ is not an aminomethyltransferase but is likely a folate-dependent regulatory protein [PMID: 15489424]. This domain could represent a folate-binding domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.