Pathways & interactions
Peptidase S24, LexA-like (IPR006197)
Short name: Peptidase_S24_LexA
Overlapping homologous superfamilies
- LexA/Signal peptidase-like superfamily (IPR036286)
- Peptidase S24, LexA-like (IPR006197)
- Transcription regulator LexA (IPR006200)
This signature defines serine peptidases belong to MEROPS peptidase family S24 (LexA family, clan SF). They include:
- LexA, the repressor of genes in the cellular SOS response to DNA damage
- MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage
- RumA a plasmid encoded homologue of UmuD [PMID: 8709953]
- RuvA, which is a component of the RuvABC resolvasome that catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair [PMID: 12423347]
The LexA, UmuD and MucD proteins interact with RecA, which activates self cleavage either derepressing transcription in the case of LexA [PMID: 10692372] or activating the lesion-bypass polymerase in the case of UmuD and MucA. UmuD'2, is the homodimeric component of DNA pol V, which is produced from UmuD by RecA-facilitated self-cleavage. The first 24 N-terminal residues of UmuD are removed; UmuD'2 is a DNA lesion bypass polymerase [PMID: 10692372, PMID: 11483531]. MucA [PMID: 9925794, PMID: 11016960], like UmuD, is a plasmid encoded a DNA polymerase (pol RI) which is converted into the active lesion-bypass polymerase by a self-cleavage reaction involving RecA [PMID: 11114935].
This group of proteins also contains proteins classified as non-peptidase homologues as they either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for catalytic activity.
- PR00726 (LEXASERPTASE)