6-phosphogluconate dehydrogenase (IPR006183)

Short name: Pgluconate_DH

Overlapping homologous superfamilies


Family relationships


This entry represents prokaryotic and eukaryotic 6PGD and a truncated prokaryotic 6PGD that lacks of a central region of about 140 residues, such as yqeC from Bacillus subtilis [PMID: 15231785]. Bacillus subtilis contains three classes of 6-phosphogluconate dehydrogenases (6PGD), including Gnd (YqjI), GntZ and YqeC. All of them are included in this entry. YgjiI is NADP+ dependent, while GntZ and YqeC are NAD+-dependent [PMID: 15231785].

6-Phosphogluconate dehydrogenase (EC: (6PGD) is a key enzyme that produces NADPH by converting 6-phospho D-gluconolactone to D-ribulose 5-phosphate in the pentose phosphate pathways (PPP) [PMID: 2113917, PMID: 6641716]. NADPH provides the major reducing power required for lipid production and protecting the cell against oxidative stress. 6PGD has been extensively studied with respect to kinetics, regulation, role in pentose-shunt production of NADPH and lipogenesis, and population genetics [PMID: 24726622]. 6PGD is associated with several human disorders including cancer and Alzheimer's disease. The structure of the budding yeast 6PGD (also known as Gnd1) has been revealed [PMID: 17570834].

Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved [PMID: 1659648]. The protein is a homodimer in which the monomers act independently [PMID: 6641716]: each contains a large, mainly alpha-helical domain and a smaller beta-alpha-beta domain, containing a mixed parallel and anti-parallel 6-stranded beta sheet [PMID: 17570834, PMID: 6641716]. NADP is bound in a cleft in the small domain, the substrate binding in an adjacent pocket [PMID: 6641716].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.