Allergen Fel d 1, chain 1 (IPR006178)

Short name: Allergen_Fel_d_I_chain1

Overlapping homologous superfamilies

Family relationships

  • Secretoglobin (IPR016126)
    • Allergen Fel d 1, chain 1 (IPR006178)


Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in Homo sapiens (Human). The nomenclature system uses the first three letters of the genus, followed by the first letter of the species name, followed by a number (additional letters can be added to the name as required to discriminate between similar designations).

Fel d 1 is allergen 1 from Felis silvestris catus (Cat) which is an important agent in human allergic reactions [PMID: 17543334]. The protein is expressed in saliva and sebaceous glands. The complete primary structure of Fel d 1 has been determined [PMID: 12851385]. The allergen is tetrameric glycoprotein consisting of two disulphide-linked heterodimers of chains 1 and 2, which have been shown to be encoded by different genes. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides.

This entry represents Fel d 1 chain 1.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.