YjgF/YER057c/UK114 family (IPR006175)

Short name: YjgF/YER057c/UK114

Overlapping homologous superfamilies

Family relationships


The YjgF/YER057c/UK114 family (also known as the Rid family) of proteins is conserved in all domains of life [PMID: 22094463]. A phylogenetic analysis applied by Lambrecht et al. has divided the Rid family into a widely distributed archetypal RidA (YjgF) subfamily and seven other subfamilies (Rid1 to Rid7) that are largely confined to bacteria and often co-occur in the same organism with RidA and each other [PMID: 25975565]. Although the family members share high levels of protein sequence and structue similarity, their functions vary widely across different species [PMID: 4632080].

Structurally, these proteins are homotrimers with clefts between the monomeric subunits that are proposed to have some functional relevance [PMID: 19899170, PMID: 12112709, PMID: 10595546].

This family includes:

  • YjgF (also known as RidA or 2-iminobutanoate/2-iminopropanoate deaminase), which displays enamine/imine deaminase activity and can accelerate the release of ammonia from reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (IlvA) [PMID: 22094463, PMID: 18296521]
  • the yeast growth inhibitor YER057c (protein HMF1) that appears to play a role in the regulation of metabolic pathways and cell differentiation [PMID: 11442631]
  • the mammalian 14.5 kDa translational inhibitor protein UK114, also known as L-PSP (liver perchloric acid-soluble protein), with endoribonucleolytic activity that directly affects mRNA translation and can induce disaggregation of the reticulocyte polysomes into 80 S ribosomes [PMID: 10400702]
  • RutC from E. coli, which is essential for growth on uracil as sole nitrogen source and is thought to reduce aminoacrylate peracid to aminoacrylate [PMID: 20400551]
  • YabJ from B. subtilis, which is required for adenine-mediated repression of purine biosynthetic genes [PMID: 10557275]

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.